Publications
2024年
Yasuhiro Nakano, Eiko Saijou, Tohru Itoh, Minoru Tanaka, Atsushi Miyajima, Taketomo Kido
Scientific Reports 2024 Apr 12. doi: 10.1038/s41598-024-58989-6
Baba T, Tomaru U, Hirao A, Mukaida N, Johmura Y
Cancer Res Commun. 2024 Mar 11. doi: 10.1158/2767-9764.CRC-23-0507. Online ahead of print.
Suda K, Moriyama Y, Razali N, Chiu Y, Masukagami Y, Nishimura K, Barbee H, Takase H, Sugiyama S, Yamazaki Y, Sato Y, Higashiyama T, Johmura Y, Nakanishi M, Kono K.
Nature Aging 2024 Feb 22. doi: 10.1038/s43587-024-00575-6. Online ahead of print.
Wong F, Zheng EJ, Valeri JA, Donghia NM, Anahtar MN, Omori S, Li A, Cubillos-Ruiz A, Krishnan A, Jin W, Manson AL, Friedrichs J, Helbig R, Hajian B, Fiejtek DK, Wagner FF, Soutter HH, Earl AM, Stokes JM, Renner LD, Collins JJ.
2023
Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis
Sonal Sinha, Satoka Aizawa, Yasuhiro Nakano, Alexander Rialdi, Hye Yeon Choi, Rajan Shrestha, Stephanie Q. Pan, Yibu Chen, Meng Li, Audrey Kapelanski-Lamoureux, Gregory Yochum, Linda Sher, Satdarshan Paul Monga, Anthoula Lazaris, Keigo Machida, Michael Karin, Ernesto Guccione & Hidekazu Tsukamoto
Nature Communications 2023 May 8. doi: 10.1038/s41467-023-38406-8
Felix Wong, Satotaka Omori , Nina M Donghia , Erica J Zheng , James J Collins
Nat Aging. 2023 May 4. doi: 10.1038/s43587-023-00415-z. Online ahead of print.
Andrea C. Postmus, Janine K. Kruit, Roos E. Eilers, Rick Havinga, Mirjam H. Koster, Yoshikazu Johmura, Makoto Nakanishi, Bart van de Sluis, Johan W. Jonker
Toxicol Appl Pharmacol 2023 Jun 1;468:116531. doi: 10.1016/j.taap.2023.116531. Epub 2023 Apr 23.
Yasuhiro Nakano, Yoshikazu Johmura
Ann Hepatol 2023 Mar-Apr;28(2):100900. doi: 10.1016/j.aohep.2023.100900.
Dan Li, Teh-Wei Wang, Sae Aratani , Satotaka Omori, Maho Tamatani, Yoshikazu Johmura, Makoto Nakanishi
J Biochem 2023 Mar 8;mvad021. doi: 10.1093/jb/mvad021. Online ahead of print.
Dan Li, Yoshikazu Johmura, Satoru Morimoto, Miyuki Doi, Keiko Nakanishi, Manabu Ozawa, Yuji Tsunekawa, Akane Inoue-Yamauchi, Hiroya Naruse, Takashi Matsukawa, Yukio Takeshita, Naoki Suzuki, Masashi Aoki, Ayumi Nishiyama, Xin Zeng, Chieko Konishi, Narumi Suzuki, Atsuya Nishiyama, Alexander Stephen Harris, Mariko Morita, Kiyoshi Yamaguchi, Yoichi Furukawa, Kenta Nakai, Shoji Tsuji, Satoshi Yamazaki, Yuji Yamanashi, Shoichi Shimada, Takashi Okada, Hideyuki Okano, Tatsushi Toda, Makoto Nakanishi
Nature Aging 2023 Jul 20. doi: 10.1038/s43587-023-00464-4. Online ahead of print.
Alexander S Harris, Sae Aratani, Yoshikazu Johmura, Narumi Suzuki, Li Dan, Makoto Nakanishi
Biochemical and Biophysical Research Communications 2023 Jun 15 ; 673:121-130. doi: 10.1016/j.bbrc.2023.06.046. Online ahead of print.
2022
Teh-Wei Wang, Yoshikazu Johmura(corresponding authors), Narumi Suzuki, Satotaka Omori, Toshiro Migita, Kiyoshi Yamaguchi, Seira Hatakeyama, Satoshi Yamazaki, Eigo Shimizu, Seiya Imoto, Yoichi Furukawa, Akihiko Yoshimura and Makoto Nakanishi(corresponding authors)
Nature 02 Nov 2022 doi: 10.1038/s41586-022-05388-4
Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung
Nabora S. Reyes, Maria Krasilnikov, Nancy C. Allen, Jin Young Lee, Ben Hyams, Minqi Zhou, Supriya Ravishankar, Monica Cassandras, Chaoqun Wang, Imran Khan, Peri Matatia, Yoshikazu Johmura, Ari Molofsky, Michael Matthay, Makoto Nakanishi, Dean Sheppard, Judith Campisi and Tien Peng
Science 378, 192–201 13 Oct 2022 doi: 10.1126/science.abf3326
Alteration of Trop-2 expression in breast cancer cells by clinically used therapeutic agents and acquired tamoxifen resistance
Jing Zhu, Wenwen Wu, Yukiko Togashi, Naoe Taira Nihira, Yoshikazu Johmura, Dajiang Zhu, Makoto Nakanishi, Yasuo Miyoshi, Tomohiko Ohta
Breast Cancer 27 Jul 2022 doi: 10.1007/s12282-022-01389-3. Online ahead of print.
Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice
Yasuhiro Nakano, Sachie Nakao, Minako Sueoka, Daigo Kasahara, Yuri Tanno, Hideaki Sumiyoshi, Tohru Itoh, Atsushi Miyajima, Katsuto Hozumi and Yutaka Inagaki
Communications Biology 2022 January 21. doi: 10.1038/s42003-022-
2021
TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis.
Suzuki N, Johmura Y (Co-corresponding authors), Wang TW, Migita T, Wu W, Noguchi R, Yamaguchi K, Furukawa Y, Nakamura S, Miyoshi I, Yoshimori T, Ohta T (Co-corresponding authors), Nakanishi M (Co-corresponding authors)
Autophagy
Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders.
Johmura Y (Co-corresponding authors), Yamanaka T, Omori S, Wang TW, Sugiura Y, Matsumoto M, Suzuki N, Kumamoto S, Yamaguchi K, Hatakeyama S, Takami T, Yamaguchi R, Shimizu E, Ikeda K, Okahashi N, Mikawa R, Suematsu M, Arita M, Sugimoto M, Nakayama KI, Furukawa Y, Imoto S, Nakanishi M (Co-corresponding authors)
Science 371, 265-270
A 3D tissue model-on-a-chip for studying the effects of human senescent fibroblasts on blood vessels.
Pauty J, Nakano S, Usuba R, Nakajima T, Johmura Y, Omori S, Sakamoto N, Kikuchi A, Nakanishi M, Matsunaga YT.
Biomaterials Science 9, 199-211
CCR2- and CCR5-mediated macrophage infiltration contributes to glomerular endocapillary hypercellularity in antibody-induced lupus nephritis.
Zoshima T, Baba T, Tanabe Y, Ishida Y, Nakatani K, Nagata M, Mukaida N, Kawano M.
Rheumatology Online ahead of print
Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation.
Sasaki SI, Zhang D, Iwabuchi S, Tanabe Y, Hashimoto S, Yamauchi A, Hayashi K, Tsuchiya H, Hayakawa Y, Baba T, Mukaida N.
Cancer Sci 112, 4883-4893
Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway.
Baba T, Yoshida T, Tanabe Y, Nishimura T, Morishita S, Gotoh N, Hirao A, Hanayama R, Mukaida N.
Cell Death Dis 12, 322
Cancer non-stem cells as a potent regulator of tumor microenvironment: a lesson from chronic myeloid leukemia.
Mukaida N, Tanabe Y, Baba T.
Mol Biomed 2, 7
Rev
2020
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16 high Cells In Vivo.
Omori S, Wang TW, Johmura Y (corresponding authors), Kanai T, Nakano Y, Kido T, Susaki EA, Nakajima T, Shichino S, Ueha S, Ozawa M, Yokote K, Kumamoto S, Nishiyama A, Sakamoto T, Yamaguchi K, Hatakeyama S, Shimizu E, Katayama K, Yamada Y, Yamazaki S, Iwasaki K, Miyoshi C, Funato H, Yanagisawa M, Ueno H, Imoto S, Furukawa Y, Yoshida N, Matsushima K, Ueda HR, Miyajima A, Nakanishi M (corresponding authors).
Cell Metabolism 32, 814-828
Two mouse models carrying truncating mutations in Magel2 show distinct phenotypes.
Ieda D, Negishi Y, Miyamoto T, Johmura Y, Kumamoto N, Kato K, Miyoshi I, Nakanishi M, Ugawa S, Oishi H, Saitoh S.
PLoS One 15, pone.0237814
FBXO22, an epigenetic multiplayer coordinating senescence, hormone signaling, and metastasis.
Johmura Y, Harris AS, Ohta T, and Nakanishi M.
Cancer Science 111, 2718-2725
Rev
Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis.
Tanabe Y, Kawamoto S, Takaku T, Morishita S, Hirao A, Komatsu N, Hara E, Mukaida N, Baba T.
Blood Adv 4, 6175-6188
Involvement of a Transcription factor, Nfe2, in Breast Cancer Metastasis to Bone.
Zhang D, Iwabuchi S, Baba T, Hashimoto SI, Mukaida N, Sasaki SI.
Cancers 12, 3003
Two-Faced Roles of Tumor-Associated Neutrophils in Cancer Development and Progression.
Mukaida N, Sasaki SI, Baba T.
Int J Mol Sci. 21, 3457
Rev
CCL4 Signaling in the Tumor Microenvironment.
Mukaida N, Sasaki SI, Baba T.
Adv Exp Med Biol 1231, 23-32
Rev
2019
Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.
Nishimura K (equally first contributed), Johmura Y (equally first contributed), Deguchi K, Jiang Z, Uchida KSK, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K, Nakanishi M.
Nat communications 10, s41467-019-08957-w
Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.
Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, Johmura Y, Yamada C, Ueda T, Takeuchi K, Yamada K, Nagata KI, Wakamatsu N, Kishi M, Pan YA, Ugawa S, Shimada S, Sanes JR, Higashi Y, Nakanishi M.
Cereb Cortex. 29, 3738-3751
A Deactivation Factor of Fibrogenic Hepatic Stellate Cells Induces Regression of Liver Fibrosis in Mice.
Yasuhiro Nakano, Akihide Kamiya, Hideaki Sumiyoshi, Kota Tsuruya, Tatehiro Kagawa, Yutaka Inagaki
Hepatology 24 September 2019 doi: 10.1002/hep.30965
2018
Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.
Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M.
Journal Clinical Investigation 128, 5603-19
Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung.
Sasaki S, Baba T, Muranaka H, Tanabe Y, Takahashi C, Matsugo S, Mukaida N.
Mol Cancer Ther 17, 1515-1525
lveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis by Generating Leukotriene B4.
Nosaka T, Baba T, Tanabe Y, Sasaki S, Nishimura T, Imamura Y, Yurino H, Hashimoto S, Arita M, Nakamoto Y, Mukaida N.
J Immunol 200, 1839-1852
Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells.
Mukaida N, Nosaka T, Nakamoto Y, Baba T.
Int J Mol Sci 20, 116
Rev
2017
The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy.
Iwata T, Uchino T, Koyama A, Johmura Y, Koyama K, Saito T, Ishiguro S, Arikawa T, Komatsu S, Miyachi M, Sano T, Nakanishi M, Shimada M.
PLoS One 12, pone.0178221
Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation.
Yamaguchi L, Nishiyama A, Misaki T, Johmura Y, Ueda J, Arita K, Nagao K, Obuse C, Nakanishi M.
Scientific Reports 7, s41598-017-00136-5
A combination of genetic and biochemical analyses for the diagnosis of PI3K-AKT-mTOR pathway-associated megalencephaly.
Negishi Y, Miya F, Hattori A, Johmura Y, Nakagawa M, Ando N, Hori I, Togawa T, Aoyama K, Ohashi K, Fukumura S, Mizuno S, Umemura A, Kishimoto Y, Okamoto N, Kato M, Tsunoda T, Yamasaki M, Kanemura Y, Kosaki K, Nakanishi M, Saitoh S.
BMC Medical Genetics 18, s12881-016-0363-6
Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia.
Mukaida N, Tanabe Y, Baba T.
Int J Mol Sci 18, 1824
Rev
Identification of a novel alpha-fetoprotein-expressing cell population induced by the Jagged1/Notch2 signal in murine fibrotic liver
Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Minako Sueoka, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
Hepatology Communications 27 March 2017 doi: 10.1002/hep4.1026
2016
HP1 regulates the localization of FANCJ at sites of DNA double-strand breaks.
Wu W, Togashi Y, Johmura Y, Miyoshi Y, Nobuoka S, Nakanishi M, Ohta T.
Cancer Science 107, 1406-1415
Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation.
Johmura Y, Yamashita E, Shimada M, Nakanishi, K., and Nakanishi M.
Scientific Reports 6, srep31194
Essential role of auto-activation circuitry on Aurora B-mediated H2AX-pS121 in mitosis.
Shimada M, Goshima T, Matsuo H, Johmura Y, Murata K, Tanaka H, Ikawa M, Nakanishi K, and Nakanishi M.
Nature Communications 8, ncomms12059
SCFfbxo22-KDM4A targets methylated p53 for degradation and regulates senescence.
Johmura Y, Sun J, Kitagawa K, Nakanishi K, Kuno T, Naiki-Ito A, Sawada Y, Miyamoto Y, Okabe A, Aburatani H, Li S, Miyoshi I, Takahashi S, Kitagawa M, and Nakanishi M.
Nature Communications 7, ncomms10574
Loss of maintenance DNA methylation results in abnormal DNA origin firing during DNA replication.
Haruta M, Shimada M, Nishiyama A, Johmura Y, Tellec BL, Debatisse M, Nakanishi M
Biochemical and Biophysical Research Communications 469, 960-966
Multiple facets of p53 in senescence induction and maintenance.
Johmura Y and Nakanishi M.
Cancer Science 107, 1550-1555
Rev
Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancerassociated fibroblast accumulation.
Tanabe Y, Sasaki S, Mukaida N, Baba T.
Oncotarget 7, 48335-48345
Gemcitabine induces cell senescence in human pancreatic cancer cell lines.
Song Y, Baba T, Mukaida N.
Biochem Biophys Res Commun 477, 515-519
MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice.
Baba T, Tanabe Y, Yoshikawa S, Yamanishi Y, Morishita S, Komatsu N, Karasuyama H, Hirao A, Mukaida N.
Blood 127, 2607-2617
Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis.
Sasaki S, Baba T, Nishimura T, Hayakawa Y, Hashimoto SI, Gotoh N, Mukaida N.
Cancer Lett 378, 23-32
Chemokines in chronic myeloid leukemia.
Mukaida N, Baba T.
Rinsho Ketsueki 57, 129-136
Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice
Sota Kodama, Yasuhiro Nakano(Co-first author), Koji Hirata1, Kenichiro Furuyama, Masashi Horiguchi, Takeshi Kuhara, Toshihiko Masui, Michiya Kawaguchi, MaureenGannon, ChristopherV. E.Wright, Shinji Uemoto and Yoshiya Kawaguchi
Scientific Reports 18 February 2016 doi: 10.1038/srep21211
2015
High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-positive T cells into tumor sites.
Naito T, Baba T, Takeda K, Sasaki S, Nakamoto Y, Mukaida N.
Cancer lett 366, 93-99
Gemcitabine-induced CXCL8 expression counteracts its actions by inducing tumor neovascularization.
Song Y, Baba T, Li YY, Furukawa K, Tanabe Y, Matsugo S, Sasaki S, Mukaida N.
Biochem Biophys Res Commun 458, 341-346
Establishment of a vascular endothelial cell-reactive type II NKT cell clone from a rat model of autoimmune vasculitis.
Iinuma C, Waki M, Kawakami A, Yamaguchi M, Tomaru U, Sasaki N, Masuda S, Matsui Y, Iwasaki S, Baba T, Kasahara M, Yoshiki T, Paletta D, Herrmann T, Ishizu A.
Int Immunol 27, 105-114
Disappearance of centroacinar cells in the Notch ligand-deficient pancreas
Yasuhiro Nakano, Naoko Negishi, Seiho Gocho, Tetsuya Mine, Yuri Sakurai, Masaki Yazawa, Koichiro Abe, Hideo Yagita, Sonoko Habu, Ryoichiro Kageyama, Yoshiya Kawaguchi, Katsuto Hozumi
Genes to Cells 27 April 2015 doi: 10.1111/gtc.12243
2014
Necessary and Sufficient role for a mitosis skip in senescence induction.
Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, Takahashi S, and Nakanishi M.
Molecular Cell 55, 73-84
CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double-strand break-specific G2 checkpoint.
Hirokawa T, Shiotani B, Shimada M, Murata K, Johmura Y, Haruta M, Tahara H, Takeyama H, and Nakanishi M.
Cancer Research 74, 3880-3889
Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-kappaB signaling pathway.
Goshima T, Shimada M, Sharif J, Matsuo H, Misaki T, Johmura Y, Murata K, Koseki H, and Nakanishi M.
Journal of Biological Chemistry, 289, 11656-116669
Crucial involvement of the CCL3-CCR5 axis-mediated fibroblast accumulation in colitis-associated carcinogenesis in mice.
Sasaki S, Baba T, Shinagawa K, Matsushima K, Mukaida N.
Int J Cancer 135, 1297-1306
Ag and IL-2 immune complexes efficiently expand Ag-specific Treg cells that migrate in response to chemokines and reduce localized immune responses.
Hamano R, Baba T, Sasaki S, Tomaru U, Ishizu A, Kawano M, Yamagishi M, Mukaida N.
Eur J Immunol 44, 1005-1015
Role of macrophage inflammatory protein (MIP)-1α/CCL3 in leukemogenesis.
Baba T, Mukaida N.
Mol Cell Oncol 1, e29899
Rev
2013
Chemokines in cancer development and progression and their potential as targeting molecules for cancer treatment.
Mukaida N, Sasaki S, Baba T.
Mediators Inflamm 2014, 170381
Rev
UHRF1-dependent H3K23 ubiquitylation couples DNA methylation and replication.
Nishiyama A, Yamaguchi L, Sharif J, Johmura Y, Kawamura T, Nakanishi K, Shimamura K, Arita K, Kodama T, Ishikawa F, Koseki H, and Nakanishi M.
Nature, 502, 249-253
Increased rotein stability of CDKN1c causes a gain-of-function Phenotype in paients with IMAGe syndrome.
Hamajima N, Johmura Y, Suzuki S, Nakanishi M, and Saito S.
PLoS One 8, pone.0075137
MIP-1alpha/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia.
Baba T, Naka K, Morishita S, Komatsu N, Hirao A, Mukaida N.
J Exp Med 210, 2661-2673
Possible implication of Fc γ receptor-mediated trogocytosis in susceptibility to systemic autoimmune disease.
Masuda S, Iwasaki S, Tomaru U, Baba T, Katsumata K, Ishizu A.
Clin Dev Immunol 2013, 345745
Rev
2012
Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.
Lee KH, Johmura Y, Yu LR, Park JE, Gao Y, Bang JK, Zhou M, Veenstra TD, Kim BY, Erikson RL, and Lee KS.
EMBO Journal 31, 3104-3117
Critical role of TNF-α-induced macrophage VEGF and iNOS production in the experimental corneal neovascularization.
Lu P, Li L, Liu G, Baba T, Ishida Y, Nosaka M, Kondo T, Zhang X, Mukaida N.
Invest Ophthalmol Vis Sci 53, 3516-3526
Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities.
Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, Kasahara M.
Am J Pathol 180, 963-972
Identification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity.
Wang YY, Taniguchi T, Baba T, Li YY, Ishibashi H, Mukaida N.
Cancer Sci 103, 107- 115
Mechanism of Fcγ receptor-mediated trogocytosis-based false-positive results in flow cytometry.
Masuda S, Iwasaki S, Tomaru U, Sato J, Kawakami A, Ichijo K, Sogo S, Baba T, Katsumata K, Kasahara M, Ishizu A.
PLoS One 7, e52918
Decrease of peripheral and intestinal NKG2A-positive T cells in patients with ulcerative colitis.
Katsurada T, Kobayashi W, Tomaru U, Baba T, Furukawa S, Ishizu A, Takeda K, Sakamoto N, Asaka M, Takeda H, Kasahara M.
PLoS one 7, e44113
Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirpalpha+ dendritic cells: a murine model.
Baba T, Badr Mel S, Tomaru U, Ishizu A, Mukaida N.
PloS one 7, e41154
Chemokines in tumor development and progression.
Mukaida N, Baba T.
Exp Cell Res 318, 95-102
Rev
Regulation of Microtubule-based Microtubule Nucleation by Mammalian Polo-like kinase.
Johmura Y, Soung NK, Park JE, Yu LR, Zhou M, Bang JK, Kim BY, Veenstra TD, Erikson RL, and Lee KS.
Poceedings of the National Academy of Sciences of the United States of America 108, 11446-11451
2011
Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice.
Fujii H, Baba T, Ishida Y, Kondo T, Yamagishi M, Kawano M, Mukaida N.
Arthritis Rheum 63, 96-106
Plasma-dependent, antibody- and Fcγ receptor-mediated translocation of CD8 molecules from T cells to monocytes.
Iwasaki S, Masuda S, Baba T, Tomaru U, Katsumata K, Kasahara M, Ishizu A.
Cytometry A 79, 46-56
2010
Polo-box domain: a versatile mediator of polo-like kinase function.
Park JE, Soung NK, Johmura Y, Kang YH, Liao C, Lee KH, Park CH, Nicklaus MC, and Lee KS.
Cellular and Molecular Life Sciences 67, 1957-1970
Rev
Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of CC Chemokine ligand 3/macrophage inflammatory protein-1alpha.
Iida N, Nakamoto Y, Baba T, Nakagawa H, Mizukoshi E, Naito M, Mukaida N, Kaneko S.
Cancer Res 70, 6556-6565
Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability.
Li YY, Wang YY, Taniguchi T, Kawakami T, Baba T, Ishibashi H, Mukaida N.
Int J Cancer 127, 474-484
Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice.
Kostadinova FI, Baba T, Ishida Y, Kondo T, Popivanova BK, Mukaida N.
J Leukoc Biol 88, 133-143
Cyclic AMP response element-binding protein is implicated in IL-6 production from arthritic synovial cells
Ishizu A, Abe A, Miyatake Y, Baba T, Iinuma C, Tomaru U, Yoshiki T.
Mod Rheumatol 20, 134-138
2009
Fad24 Causes Hyperplasia in Adipose Tissue and Improves Glucose Metabolism.
Johmura Y, Watanabe K, Kishimoto K, Ueda T, Shimada S, Osada S, Nishizuka M, and Imagawa M.
Biological and Pharmaceutical Bulletin 32, 1656-1664
Crucial contribution of thymic Sirp alpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner.
Baba T, Nakamoto Y, Mukaida N.
J Immunol 183, 3053-3063
Exclusive expression of proteasome subunit {beta}5t in the human thymic cortex.
Tomaru U, Ishizu A, Murata S, Miyatake Y, Suzuki S, Takahashi S, Kazamaki T, Ohara J, Baba T, Iwasaki S, Fugo K, Otsuka N, Tanaka K, Kasahara M.
Blood 113, 5186-5191
Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells.
Li YY, Wu Y, Tsuneyama K, Baba T, Mukaida N.
Cancer Sci 100, 396-404
2008
FAD24, a regulator of adipogenesis and DNA replication, inhibits H-RAS-mediated transformation by repressing NF-kappaB activity.
Johmura Y, Suzuki M, Osada S, Nishizuka M, and Imagawa M.
Biochemical and Biophysical Research Communications 369, 464-47
FAD24 acts in concert with histone acetyltransferase HBO1 to promote adipogenesis by controlling DNA replication.
Johmura Y, Osada S, Nishizuka M, and Imagawa M.
Journal of Biological Chemistry 283, 2265-2274
FAD24, a regulator of adipogenesis, is required for the regulation of DNA replication in cell proliferation.
Johmura Y, Osada S, Nishizuka M, and Imagawa M.
Biological and Pharmaceutical Bulletin 31, 1092-1095
CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process.
Wu Y, Li YY, Matsushima K, Baba T, Mukaida N.
J Immunol 181, 6384-6393
Tumor cell apoptosis induces tumor-specific immunity in a CC chemokine receptor 1- and 5-dependent manner in mice.
Iida N, Nakamoto Y, Baba T, Kakinoki K, Li YY, Wu Y, Matsushima K, Kaneko S, Mukaida N.
J Leukoc Biol 84, 1001-1010
Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression.
Lu P, Li L, Kuno K, Wu Y, Baba T, Li YY, Zhang X, Mukaida N.
J Immunol 180, 4283-4291
Rat CD4+CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism.
Baba T, Iwasaki S, Maruoka T, Suzuki A, Tomaru U, Ikeda H, Yoshiki T, Kasahara M, Ishizu A.
J Immunol 180, 2999-3006
2007
Characterization of novel genes regulating adipocyte differentiation.
Johmura Y (Corresponding authors)
Yakugaku Zasshi 127, 135-142
Rev
2006
MHC class I-like MILL molecules are beta2-microglobulin-associated, GPI-anchored glycoproteins that do not require TAP for cell surface expression.
Kajikawa M, Baba T, Tomaru U, Watanabe Y, Koganei S, Tsuji-Kawahara S, Matsumoto N, Yamamoto K, Miyazawa M, Maenaka K, Ishizu A, Kasahara M.
J Immunol 177, 3108-3115
Role of neuronal interferon-gamma in the development of myelopathy in rats infected with human T-cell leukemia virus type 1.
Miyatake Y, Ikeda H, Ishizu A, Baba T, Ichihashi T, Suzuki A, Tomaru U, Kasahara M, Yoshiki T.
Am J Pathol 169, 189-199
CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype.
Baba T, Ishizu A, Iwasaki S, Suzuki A, Tomaru U, Ikeda H, Yoshiki T, Kasahara M.
Blood 107, 2004-2012
2005
SLC39A14, a LZT protein, is induced in adipogenesis and transports zinc.
Tominaga K, Kagata T, Johmura Y, Nishizuka M, and Imagawa M.
FEBS Journal 272, 1590-1599
Malignant transformation of thymoma in recipient rats by heterotopic thymus transplantation from HTLV-I transgenic rats.
Tsuji T, Ikeda H, Tsuchikawa T, Kikuchi K, Baba T, Ishizu A, Yoshiki T.
Lab Invest 85, 851-861
Chronic graft-versus-host disease-like autoimmune disorders spontaneously occurred in rats with neonatal thymus atrophy.
Baba T, Ishizu A, Ikeda H, Miyatake Y, Tsuji T, Suzuki A, Tomaru U, Yoshiki T.
Eur J Immunol 35, 1731-1740
Aberrant gene expression by CD25+CD4+ immunoregulatory T cells in autoimmune-prone rats carrying the human T cell leukemia virus type-I gene.
Hayase H, Ishizu A, Ikeda H, Miyatake Y, Baba T, Higuchi M, Abe A, Tomaru U, Yoshiki T.
Int Immunol 17, 677-684
The role of IFN-gamma in cattle infected with Theirelia sergenti.
Hagiwara K, Tokuda M, Baba T, Yamanaka H, Kirisawa R, Tsuji M, Ishihara C, Iwai H.
Vet Parasitol 127, 105-110.
2004
Fad24, a mammalian homolog Noc3p, is a positive regulator in adipocyte differentiation.
Tominaga K, Johmura Y, Nishizuka M, and Imagawa M.
Journal of Cell Science 17, 6217-6226
The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis.
Tominaga K, Kondo C, Johmura Y, Nishizuka M, and Imagawa M.
FEBS Letters 577, 49-54
Hematopoietic progenitor cells as possible origins of epithelial thymoma in a human T lymphocyte virus type I pX gene transgenic rat model.
Tsuchikawa T, Ikeda H, Kikuchi K, Tsuji T, Baba T, Ishizu A, Tanaka Y, Kato H, Yoshiki T.
Lab Invest 84, 245-252